Clyde Shelton (Gerard Butler) is an upstanding family man whose wife and daughter are brutally murdered during a home invasion. When the killers are caught, Nick Rice (Jamie Foxx), a hotshot young Philadelphia prosecutor, is assigned to the case. Over his objections, Nick is forced by his boss to offer one of the suspects a light sentence in exchange for testifying against his accomplice. Fast forward ten years. The man who got away with murder is found dead and Clyde Shelton coolly admits his guilt. Then he issues a warning to Nick Either fix the flawed justice system that failed his family, or key players in the trial will die. Soon Shelton follows through on his threats, orchestrating from his jail cell a string of spectacularly diabolical assassinations that can be neither predicted nor prevented. Philadelphia is gripped with fear as Shelton's high-profile targets are slain one after another and the authorities are powerless to halt his reign of terror. Only Nick can stop the killing, and to do so he must outwit this brilliant sociopath in a harrowing contest of wills in which even the smallest misstep means death. With his own family now in Shelton's crosshairs, Nick finds himself in a desperate race against time facing a deadly adversary who seems always to be one step ahead.

Johnny Knoxville reprises his JACKASS role as 86-year-old Irving Zisman in the story of a crotchety old man unexpectedly saddled with the care of his 8-year-old grandson Billy (Jackson Nicoll). The two generations of troublemakers soon develop a bond, as they hustle their way across the heartland of America on an outrageous road trip with a whole lot of hijinks and pranks on unsuspecting, real-life people - all of whom had no idea they were starring in a hidden camera comedy.