With the IMF disbanded, and Ethan (Tom Cruise) out in the cold, the team now faces off against a network of highly skilled special agents, the Syndicate. These highly trained operatives are hellbent on creating a new world order through an escalating series of terrorist attacks. Ethan gathers his team and joins forces with disavowed British agent Ilsa Faust (Rebecca Ferguson), who may or may not be a member of this rogue nation, as the group faces their most impossible mission yet.

The previous season of The Walking Dead ended with Rick and the group outgunned, outnumbered, and trapped in a train car awaiting a grim fate. What follows is a story that weaves the true motives of the people of Terminus with the hopeful prospect of a cure in Washington, D.C., the fate of the group's lost comrades, as well as new locales, new conflicts, and new obstacles in keeping the group together and staying alive. Stories will break apart and intersect. The characters will find love and hate. Peace and conflict. Contentment and terror. And, in the quest to find a permanent, safe place to call home, one question will haunt them. After all they've seen, all they've done, all they've sacrificed, lost, and held on to no matter what the cost. Who do they become?