No, the Bose Noise-Masking Earbuds cannot be used to make phone calls. Nor can they be used to listen to music, podcasts, or any other digital content you may have. They are essentially white noise machines that you put in your ears. They are designed to pair only through the Bose Sleep app, and the only sounds they can play are predetermined by the app. Whether or not this will change is anyone's guess, but for the time being their use is strictly limited to playing sounds designed to help drown out background noise and help people sleep.