Following the deadly Langley bombing that is blamed on disgraced congressman Nicholas Brody (Damian Lewis) and having helped him escape the U.S., Carrie Mathison (Claire Danes) is desperate to solve the case and clear Brody's name as the third season of the conspiracy thriller begins. But Carrie's efforts are threatened when she becomes the focus of a hostile Senate investigation led by Sen. Andrew Lockhart (Tracy Letts) who believes the CIA is covering up the truth about the attack. Saul Berenson (Mandy Patinkin), now CIA chief, also feels the heat of the probe and it begins to undermine his efforts to revive the Agency. Trouble also brews in the Brody household when Dana (Morgan Saylor) starts exhibiting destructive behavior and runs away from home. As for Brody, who has a $10 million bounty on his head, he begins to recuperate from a gunshot wound in Venezuela where he is held captive by armed gunmen in a ramshackle Caracas building called the Tower of David. With no passport, no money and no chance of escape, Brody slowly begins to realize that he may have to live out the rest of his days in this slum dwelling where Carrie has arranged for him to at least be safe.

From the Marvel Universe come the agents of S.H.I.E.L.D., ready to defend the citizens of the world. In the aftermath of the battle between invading aliens and the Earth's mightiest heroes, the Avengers, the special law-enforcement agency S.H.I.E.L.D. begins to intensively recruit new agents to investigate bizarre events and superhuman sightings. Led by Agent Phil Coulson (Clark Gregg), this mismatched team of super spies, geeky scientists, sneaky con artists and regular Joes with extraordinary gifts will have to come together as the first line of defense against the evil forces who seek to corrupt and destroy.