Season 1 of the crime drama begins with forensic anthropologist Temperance "Bones" Brennan (Emily Deschanel) back in D.C. after months away identifying genocide victims. Agent Seeley Booth (David Boreanaz) promptly hijacks her to help him with a case. Brennan initially refuses, but her boss at the Jeffersonian Institute, Dr. Daniel Goodman (Jonathan Adams), insists that part of her job is being lent out to the FBI. She agrees to work with Booth, but only if she can be his partner in all areas of the cases. The first of these cases establishes the premise for the next 21 episodes. After a body surfaces, the remains are transferred to the Jeffersonian, where Brennan and her devoted "squints" leap to action. Brennan's team includes her assistant, the socially inept but brilliant Zack Addy (Eric Millegan); bugs and slime expert Dr. Jack Hodgins (T.J. Thyne); and her best friend, forensic artist Angela Montenegro (Michaela Conlin). The main suspect turns out to be a powerful senator, but despite warnings from the FBI to stay away, Brennan continues with her investigation. Throughout the season, Brennan and Booth are devoted to uncovering the truth, repeatedly finding themselves in dangerous situations and relying on each other for backup. Booth eventually confides to Brennan that he wants to bring closure to victims' loved ones to make up for the lives he took in his sniper past. Brennan, meanwhile, is dedicated to identifying the deceased as a result of the mysterious disappearance of her parents years ago. The duo work together to solve crimes involving small-town cannibals, promiscuous private-school teens and a homeless society in an underground tunnel. As each case draws to a close, the bantering pair grow more intimate, a closeness heightened during the season finale, when unearthed bones provide a link to Brennan's past that may reunite her with the family she thought was lost forever.

After thwarting last season's attempted nuclear attack on Los Angeles, Day 3 finds Counter Terrorist Unit agent Jack Bauer (Kiefer Sutherland) again fighting to protect the city, this time from a weaponized virus. But Jack is also battling a personal demon---a heroin addiction he picked up while working undercover in a drug-smuggling ring run by terrorist Ramon Salazar (Joaquim de Almeida). At Jack's side throughout Day 3 is his daughter, Kim (Elisha Cuthbert), who took a desk job at CTU in the time between Seasons 2 and 3. Complicating matters is Kim's relationship with Jack's new partner, Chase Edmunds (James Badge Dale), whom she has been secretly dating. Further CTU romance is found between agents Tony Almeida (Carlos Bernard) and Michelle Dessler (Reiko Aylesworth), whose working relationship has blossomed into marriage. But it's a rocky union that's tested throughout Day 3, by everything from charges of terrorism to exposure to a deadly virus. Following the dissolution of his marriage to the first lady, President David Palmer (Dennis Haysbert) is deep into his reelection campaign. But privately he is still grappling with the lingering effects of the viral attack carried out by assassin Mandy (Mia Kirshner) during Day 2's final moments. New to the series is Chloe O'Brian (Mary Lynn Rajskub), a CTU senior analyst whose computer skills prove helpful during Jack's mission this season and beyond. Day 3 also features the first appearance of Wayne Palmer (DB Woodside), who serves as the new chief of staff for his older brother. While lacking in major guest stars, Day 3 does feature Zachary Quinto ("Heroes") as rookie computer analyst Adam Kaufman, and Daniel Dae Kim ("Lost"), who returns for a second go-round as CTU agent Tom Baker.

With a new day comes a new leader for the sixth season, as Wayne Palmer (DB Woodside), brother of former president David Palmer, has taken the reins from the corrupt Charles Logan (Gregory Itzin). But President Palmer has little time to celebrate his election, as America faces yet another grave threat, this one from Islamic terrorist Abu Fayed (Adoni Maropis). By way of introduction, Fayed orders suicide bombings of 10 U.S. cities over a period of 11 weeks. But he's just getting warmed up-before Day 6 comes to a close, the threat goes nuclear. Trying to prevent further bloodshed, as always, is Jack Bauer (Kiefer Sutherland). Out of the frying pan and into the fire, Jack is freed after months of torture in a Chinese prison, only to be handed over to Fayed in exchange for seemingly valuable intel. Tackling the day's dangers on the CTU front are new personnel additions Mike Doyle (Rick Schroder), who replaces the fallen Curtis Manning as director of field operations, and Agent Milo Pressman (Eric Balfour), who has a history of butting heads with his new boss. Day 6 also provides the first glimpse of Jack's blood relatives, his father Phillip (James Cromwell) and brother Graem (Paul McCrane). But it's far from a touching family reunion, as one of Jack's toughest challenges is determining where the other Bauers' loyalties lie. Several new faces make their way to 1600 Pennsylvania Ave., including steely vice president Noah Daniels (Powers Boothe) and presidential advisers Reed Pollock (Chad Lowe) and Thomas Lennox (Peter MacNicol), each of whom has his own agenda. Making a surprise return later in the day are former president Logan, his ex-wife Martha (Jean Smart), and former Secret Service agent Aaron Pierce (Glenn Morshower), all of whom play brief but pivotal roles in the season's developments.

This set serves up all 23 episodes from the sixth season of the hit FOX series Bones, starring Emily Descanel as a forensic specialist and David Boreanaz as her FBI agent partner and possible love interest.