When their attempt to rob a casino owned by the feared gangster Pope (Robert de Niro) goes awry and a shootout ensues, Vaughn (Jeffrey Dean Morgan) and Cox (Dave Bautista) are forced to flee on foot and hijack city Bus 657 and take the passengers hostage. Now, in a high speed chase, Vaughn will not only have to outwit the police, led by Officer Bajos (Gina Carano) who are in hot pursuit, but he will have to contend with Pope's maniacal right hand man, Dog (Morris Chestnut), in order to make it through the day alive. But we quickly learn that things are not what they seem, and Vaughn has more than one card up his sleeve.

During a post-Civil War Wyoming winter, a stagecoach bearing a bounty hunter (Kurt Russell), his foul-mouthed prize (Jennifer Jason Leigh), an ex-Union officer (Samuel L. Jackson) and a lawman (Walton Goggins) makes it's way towards Red Rock. The worsening snows force them to shelter at a general store occupied by a caretaker (Demian Bichir), a cowboy (Michael Madsen), Red Rock's hangman (Tim Roth), and an aged Confederate general (Bruce Dern). As the blizzard traps them within-possibly with no escape-resentments, greed, and hidden agendas emerge that might destroy them before the elements do, in Quentin Tarantino's moody and stylish sagebrusher.