yes. I have 2 of these mounted to a VESA arm. I use DisplayPort cables to go to the 2 DisplayPort slots in my GTX 1080 ti. depending on what you're connecting to, you may have to get creative. but if it's a desktop computer with a graphics card, odds are you'll have 2 slots that will work for dual monitors. laptops too, but you may need a splitter or something.