Former United Nations employee Gerry Lane (Brad Pitt) is called upon to help stop the chaotic pandemic that has gripped populations around the world. Lane fights to keep his family safe, while searching for an answer to the outbreak before it destroys all of civilization.

Lincoln Six-Echo is a resident of a seemingly utopian but contained facility in the mid-21st century. Like all of the inhabitants of this carefully controlled environment, Lincoln hopes to be chosen to go to the The Island, reportedly the last uncontaminated spot on the planet. - But Lincoln soon discovers that everything about his existence is a lie. He and all of the other inhabitants of the facility are actually human clones whose only purpose is to provide spare parts for their original human counterparts. - Realizing it is only a matter of time before he is harvested, Lincoln makes a daring escape with a fellow resident named Jordan Two-Delta. Pursued by the forces of the institute that once housed them, Lincoln and Jordan engage in a race for their lives to literally meet their makers.