Michelangelo, Donatello, Leonardo, and Raphael are back to battle bigger, badder villains, alongside April O'Neil (Megan Fox), Vern Fenwick (Will Arnett), and a newcomer the hockey-masked vigilante Casey Jones (Stephen Amell). After supervillain Shredder escapes custody, he joins forces with mad scientist Baxter Stockman (Tyler Perry) and two dimwitted henchmen, Bebop (Gary Anthony Williams) and Rocksteady (WWE Superstar Stephen InchSheamusInch Farrelly), to unleash a diabolical plan to take over the world. As the Turtles prepare to take on Shredder and his new crew, they find themselves facing an even greater evil with similar intentions the notorious Krang.

During a post-Civil War Wyoming winter, a stagecoach bearing a bounty hunter (Kurt Russell), his foul-mouthed prize (Jennifer Jason Leigh), an ex-Union officer (Samuel L. Jackson) and a lawman (Walton Goggins) makes it's way towards Red Rock. The worsening snows force them to shelter at a general store occupied by a caretaker (Demian Bichir), a cowboy (Michael Madsen), Red Rock's hangman (Tim Roth), and an aged Confederate general (Bruce Dern). As the blizzard traps them within-possibly with no escape-resentments, greed, and hidden agendas emerge that might destroy them before the elements do, in Quentin Tarantino's moody and stylish sagebrusher.