Interstellar opens on Earth in the distant future, as Mother Nature is waging war on humanity. Famine is widespread, and all of mankind's resources are now dedicated to farming in a desperate fight for survival. A former NASA pilot and engineer named Cooper (Matthew McConaughey) has become a homesteader in order to support his teenage son Tom (Timothee Chalamet) and 10-year-old daughter Murph (Mackenzie Foy). Unfortunately, even that begins to look like a futile endeavor after a sandstorm ravages their close-knit community. Meanwhile, a seemingly supernatural mystery begins to unfold when the InchghostInch that dwells in Murph's room sends her a mysterious set of coordinates - which lead the curious father/daughter duo to a clandestine underground base housing the remnants of NASA. There, renowned physicist Professor Brand (Michael Caine) has been working with a team of astronauts and scientists to find a new planet capable of sustaining human life. Brand quickly persuades Cooper to pilot a mission that will hopefully carry the seeds of human life to a habitable planet in another galaxy. Cooper is soon bound for space with Brand's daughter Amelia (Anne Hathaway) and researchers Doyle (Wes Bentley) and Romilly (David Gyasi).

Cellular biologist Lena's (Natalie Portman) husband Kane (Oscar Isaac) suddenly returns from a mysterious region known as the Shimmer after being missing for a year. When Kane falls into a coma, Lena joins a scientific expedition to the area where she and the rest of her team encounter mutated creatures and strange hybrids of plant and animal life while realizing that they themselves are being altered in bizarre ways. Based on Jeff VanderMeer's novel, this visually stunning sci-fi tale co-stars Jennifer Jason Leigh, Gina Rodriguez, Tessa Thompson.