Following immediately after the events of THE RAID, Rama (Iko Uwais) is forced to reinvent himself as an undercover cop in order to provide protection for his wife and child. Working for the anti-corruption taskforce led by the one person he can trust, Bunawar, he is given a mission to engage himself as an enforcer for a local mob boss, Bangun. Finding a way in through Bangun's son Uco, Rama must hunt for information linking Bangun with police force corruption. All the while, he harbors a dangerous and personal vendetta for revenge and justice that threatens to consume him, and bring both this mission and the organized crime syndicates crashing down.

With the IMF disbanded, and Ethan (Tom Cruise) out in the cold, the team now faces off against a network of highly skilled special agents, the Syndicate. These highly trained operatives are hellbent on creating a new world order through an escalating series of terrorist attacks. Ethan gathers his team and joins forces with disavowed British agent Ilsa Faust (Rebecca Ferguson), who may or may not be a member of this rogue nation, as the group faces their most impossible mission yet.