RAM compatibility is a multi staged answer. I would first suggest you look up your motherboard's website and there should be a tab there that will list a very long list of RAM manufacturer's and tell you whether or not it's supported. Additionally, if you're replacing old RAM are you replacing all 4 sticks? Or just two? Because if you've got already got 4 in your system, but only replacing two, there could be an issue there. My understanding is that you want the RAM to match with whatever other RAM you have in the other slots. Lastly, actually installing RAM is actually very easy, push back two tabs, slot in RAM, push down on RAM and listen for click. Just need to be careful the gap lines up.