Yes. Most 3DS games will play on a 2DS. I say most because it depends on which 2ds you have. If you have a flat 2ds there are certain 3ds games that won't work. They are marked as "only for new 3ds"on the box. The only games I know of that are only work on certain 3ds and 2ds systems are Xenoblade Chronicles and Fire Emblem Warriors. If you have the 2ds XL, which folds in half, then you can play anything.