Yes this will work in a GMC Sierra. I have a 1999 Cadillac Seville and it’s perfect for my vehicle. I chose to use the station 88.1 and I have no issues. I’d say to disconnect it when getting out of your vehicle as when turning your car on/off your Bluetooth will stay connected as long as this is powered on. And the built in charger is amazing!!! I hope this helps you out and I hope you enjoy this product as much as I do. It’s saved me a lot of money as I didn’t want to replace the original radio.