Yes the Dpi can be adjusted. It can even be adjusted on the fly using mouse buttons G10 & G11 (by default.) Logitech's Gaming Software allows you to program the buttons on the mouse at will by simply opening the application. So, if you didn't want to use those buttons ( I leave mine that way) you could change them. Logitech's Gaming Software will also allow you to change the amount by which the Dpi will change when you hit the buttons. The software is free and straightforward to use, even if you aren't a computer wiz!