That's a good question. I would guess if your system has a Sub out, it would work. I just don't see that happening because most Bose systems are powered through it's Sub so why would they give us that option? I wish they would because their subs lack Bass. I am thinking of just selling mine and upgrading, don't get me wrong, they sound nice but you can only get so much out of them little speakers. Sorry I wasn't much help but hopefully you will get your answer.