The hub uses infrared for control. I believe if you have wifi enabled components that are compatible with Harmony you can control them through the app or through one of the more robust remotes. But for the hub to control a cable box or dvd player for instance it will need to be able to target them with infrared. They say if all the devices are in the same cabinet it should work. I would attempt it and if you have trouble try repositioning the hub, it's rather small, until you find the sweet spot. If it doesn't work then return it to Best Buy and inquire about another solution.