Theoretically yes...while I've only done it with a nook color...the theory holds water based on looking at the setting options in my nook Simple Touch.
My household owns: nook Color, nook Tablet, nook HD, and now a nook Simple Touch (eyestrain...wanted the E-Ink screen!!).
My first nook was the nook Color. When I upgraded to the nook Tablet (not *that* much of an upgrade compared to the HD & HD+!!), I gave my Color to my daughter with her own account installed...but first I had to yank my account & books off of it.
In the settings, somewhere you should find the option "Erase & Deregister device" (in the nook Simple Touch I have with me today...it's under "Settings>Device Info>Erase & Deregister Device".
This will bring up a screen which says:
"This will remove all digital books & files, including side-loaded content, from this device. The titles you have purchased will remain in your B&N account"
Then a large button saying "Erase & Deregister Device"
There may be some slight screen differences, but that's the concept of what you're looking for in order to make it open to your account.
I used this feature to clear everything I'd done on my nook Color in order to start it from fresh for my daughter. Once it was done with the process, it then walks you back through the registration process where you will provide it with your own Barnes & Noble account info and go from there.
Hope this helps! Love my nooks, bigtime!