In my experience, as long as the wireless remote device is connected to the correct USB port, they should work. Some older wireless mice might not work with newer laptops. Husband bought brand new laptop (February 2017) and only 2 of the 6 or more USB ports on the laptop would work with the unifying receiver. Because there are so many different types of USB ports now: USB 2.0; 3.0; superspeeds aka SS (USB 3.1 for 5 GB, for 10 GB and so on...) So it really depends. I recommend shopping around and asking a lot of questions.