Not without another device. I don't know of any TV's with the Google Assistant built-in. If there was, it might work. However, you can pickup a Harmony Hub/Remote and it will work. I do this now for my TV, receiver, cable box, PS4, etc. I can tell my either my Echo Dot or Home Mini and issue commands to turn on/off my system, change channels, etc. Some commands can be a little finicky, and you have to do some customizing to get certain things working right (this is all on the Harmony side). I still have some issues with my system, but overall the majority of my commands work. There are several versions from Logitech, so check their website to see which remotes are compatible with Alexa or Google Assistant. I have the top of the line Harmony Elite.

It does not include a USB cable. You'll need to purchase one if that's how you intend to connect it, which USB cables are cheap, and you can use your old cable if you have one.

You may need check the settings that display on-screen. Then you need to look at the preferred output method setting for that particular input connection. You can specify to tell that device to use specific output.