You just answered your own question and that is a limitation of the file system (FAT32, NTFS, etc) not of the drive itself. if your DVR/TIVO/TV/whatever has a limitation of what it can see then you have to work within that limitation.
Link to this answer more directly from Microsoft's own answer site. http://answers.microsoft.com/en-us/windows/forum/windows_7-files/what-is-the-maximum-file-size-fat-fat32-ntfs-file/1663db6b-490e-4021-9e36-f7a6976ac0c0