If you have a pci express port and the space for it, it will fit and work in any desktop computer case.
For drivers you will want some beta drivers from http://maxedtech.com/asus-xonar-unified-drivers/ to fix the rear channel problem (out of sync) for analog 5.1 speakers as Asus does not make updates for it any more.
Great card, I use Triton pro+ 5.1 with analog adapter. In Lenovo y900 case.