Yes. I used this (micro-SD card) in my Garmin Nuvi 50 for extensive travel throughout central Europe this fall, and it worked beautifully on city streets, major highways, and rural country roads. I was even able to pre-program our selected hotels and points of interest as Favorites before departing the US. It even worked better and appeared to be more up-to-date than the on-board GPS in our rental car. Highly recommended!