Yes, it will work with pretty much any processor that runs on a motherboard with a PCI express slot. One of my computers I'm running it on is a 13 year Pentium core 2 duo and there isn't any issue. The other computer I have one in is a Ryzen 5 3600, but it will work with any Ryzen as long as you have enough room in your case and your power supply supports it. You'll need both a 8 pin pcie and 6 pin pcie cable.