A SSD drive is no different than a regular hard disk drive when it comes to installation and connection to the motherboard as long as the drive interface is the same (SATA connection on the motherboard of the computer and SATA connection on the hard drive). I've swapped out "regular" spinning platter based hard drives with SSD drive on many computers (desktops and laptops) and all have worked very well. In fact, I prefer to use SSD drives on laptops because the SSD drives are all solid state memory chips with no moving parts. It also uses less power. The benefits of using the SSD in a laptop is since it has no moving parts you can't induce read/write errors with hard bumps or knocks while the drive is in use reading or writing data. In a desktop installation, since you're not going to carry it around as you would a laptop while using it the benefits of "no moving parts" are not as valuable however, the increase in data access speed is. If your desktop computer already has a 2.5" hard drive slot available the 2.5" SSD drive will fit perfectly. The mounting screw holes will line up perfectly and you should have no problems mounting the drive. If you only have the larger hard drive slots (for the 3.5" drives) you can use an adapter that you mount the 2.5" drive on to then mount the adapter into the 3.5" drive slot.