A:
I don't know for certain, but this link should help: https://epson.com/Support/Scanners/Perfection-Series/Epson-Perfection-V550-Photo/s/SPT_B11B210201?review-filter=macOS+10.13.x.
The User's Guide (copyright 2013) only says:
Mac System Requirements
Make sure your system meets these requirements before using it with your scanner.
System Mac OS X 10.8.x, 10.7.x, 10.6.x, 10.5.8
(Fast user switching on Mac OS X is not supported.)
Interface Macintosh USB
Display Color monitor with 1024 × 768 resolution or higher and support for
millions of colors
Note: Epson Scan does not support the UNIX File System (UFS) for Mac OS X. Install Epson Scan on a
disk or in a partition that does not use UFS.