Hello Jmay, thanks for asking! You can remove the pre-installed screen protector if you want to replace it with a new screen protector. However, glass screen or silicone/gel case screen protectors are unlikely to be compatible, and plastic film protectors cannot be thicker than 0.2 mm. Samsung cannot guarantee compatibility with any third-party screen protectors. Make sure your new screen protector is Samsung certified. Look for the Designed for Samsung logo for Samsung approved accessories. ^Elizabeth