A:
The Logitech m310 wireless mouse is compatible with the following operating Systems: Windows XP, Windows Vista, Windows 7,Windows 8, Mac OS X 10.4.x or later.
The Software Apps required are: SetPoint, Logitech Control Center, Connect.exe. or Replaceable.
As long as your Dell Optiplex gx620 has a working USB 2.0 port, then this mouse will work with your computer.