A:
This Toshiba 2TB USB 3.0 external drive is just a USB drive, so it has little or nothing to do with it working with whatever computer you have. That is to say, there are no compatibility issues with anything in your computer, as long as it supports USB.
Furthermore, since this is a USB 3.0 drive, in order to get its high performance, you should use it on a USB 3.0 port. If your computer only has USB 2.0 ports, it will still work, but at a much degraded performance level.
So, in conclusion, USB drives have nothing to do with SATA or anything else inside your computer, other than it having USB support.